12月6日 Karine Gauthier:Selective activation/inactivation of the thyroid hormone signaling pathway in the neurons: the metabolic consequences(生命科学系列校级学术报告)


报告人简介:

KarineGauthier has been working in the thyroid hormone field for the last 20 years orso. She did her PhD in the Lab of Jacques Samarut (1996-2000) at the ENS inLyon. She generated during these years several of the knock-out mice currentlyused in a number of labs to study Thyroid Hormone Receptors (TR) function.  She participated to the early collaborativeeffort to characterize those mice, for a better understanding of TR rolesduring early postnatal development. She then moved for her postdoctoral trainingto David Mangelsdorf’s Lab at UTSW Medical Center in Dallas where she was anHHMI research associate (2001-2004). She kept on studying there nuclearreceptors function using knock-out mouse models. She had special interest infinding new ligands for PXR and in studying the role of LXR in fat metabolismand macrophage functions. She came back in France in 2004 as a permanentinvestigator in Jacques Samarut lab, where she directed a small group ofpeople. She studies the role of Thyroid Hormones and TR in the control of lipidand glucose metabolism in peripheral tissues and their involvement in metabolicdiseases development. She obtained her HDR (habilitation to direct research) in2013. She is currently working at the IGFL in Lyon in the group of FrédéricFlamant. The focus of her studies is now to understand how endogenous brainsignaling is involved in regulating energy expenditure, using both tissueselective inhibition and activation of TR in mice.

She participates to a EuropeanNetwork on nuclear receptors and coordinates an ANR project headed by JacquesSamarut. She has a total number of 33 publications all in well recognizedinternational journals.

She is a member of the ETA,reviews papers for ATVB ,molecular endocrinology, endocrinology, scientificreports, and Plos one regularly and has been selected or invited to give talksin many national and international congresses in the past years. She has beenpart of many PhD defense committees.




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